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Protein Physicist

KAMIL
TAMIOLA,PhD

Kamil Tamiola

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I work with Folded and Intrinsically Disordered Proteins

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I have done my research at University of Cambridge, UK and University of Groningen, NL. During my Top-Master in Biomolecular Sciences and Doctoral programmes, I have worked on numerical modelling of Intrinsically Disordered Proteins from sparse NMR spectroscopy data and Molecular Dynamics simulations. I am a founder and CEO of Peptone — The Protein Intelligence Company.

If you want to learn more about my research, read my PhD Thesis.

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AI & Quantum Computing

I am currently invovled in the development of AI and quantum computing methods for rapid calculation of therapeutic protein models from sparse experimental data, including NMR spectroscopy, Cryo-EM Tomography and various low-resolution biophysical techniques.

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I am very much interested in protein aggregation and pharmaceutical developability issues. A major part of my scientific curriculum has evolved around the development of accurate charge-charge interaction models for non-canonical protein states, e.g. the 'random-coil'. Together with my team at Peptone — The Protein Intelligence Company, we are looking for smart and autonomous ways to reconcile atomistic-resolution experiments with next-generation computing methods, including quantum computing and quantum optimisation.
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Selected publications by Kamil Tamiola

Research

"Controlled long-exposure imaging of a celestial object." Tamiola K.;Toma L. USA Patent Office 2016, 15/034, 488 Source: US Patent App. 15/034,488152

"Structural propensity database of proteins" Tamiola K.; Heberling M.M.; Domanski J.; bioArxiv, 2017DOI: https://doi.org/10.1101/144840

"pepKalc: scalable and comprehensive calculation of electrostatic inter-actions in random coil polypeptides." Tamiola K.; Scheek R.M.; van der Meulen P.; Mulder F.A.A. Bioinformatics 2018, bty033DOI: 10.1093/bioinformatics/bty0339.2

"Preparation of D-amino acids by enzymatic kinetic resolution using amutant of penicillin-G acylase from E. coli." Carboni C.; Kierkels H.G.T;,Gardossi L.;Tamiola K.; Janssen D.B.;, Quaedflieg P.J.L.M. Tetrahedron:Asymmetry, 2006, 17(2), 245–251. DOI: 10.1016/j.tetasy.2005.12.023

"Deeply branching c6-like cytochromes of cyanobacteria." Bialek W.;Nelson M.;Tamiola K.; Kallas T.; Szczepaniak A. Biochemistry2008,47(20), 5515–22.DOI: 10.1021/bi701973g

"Probing the free energy landscape of the FBP28WW domain usingmultiple techniques." Periole X.; Allen L.R.;Tamiola K.; Mark A.E.;Paci E. J. Comput. Chem. 2009, 30(7), 1059–68.DOI: 10.1002/jcc.21128

"Sequence-specific random coil chemical shifts of intrinsically disor-dered proteins." Tamiola K.; Acar B.; Mulder F.A.A. J. Am. Chem. Soc.2010, 132, 18000–3.DOI: 10.1021/ja105656t

"ncIDP-assign: a SPARKY extension for the effective NMR assignment ofintrinsically disordered proteins." Tamiola K.; Mulder F.A.A. Bioinformatics 2011, 27, 1039–40.DOI: 10.1093/bioinformatics/btr054

"Using NMR chemical shifts to calculate the propensity for structuralorder and disorder in proteins." Tamiola K.; Mulder F.A.A.Biochem. Soc. Trans. 2012, 40, 1014–1020.DOI: 10.1042/BST20120171

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Multiscale Protein Modelling  

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I AM HIRING

I am looking for passionate candidates who want to work on the most challenging projects in Big Pharma industry.
Apply here